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簡(jiǎn)要描述： MBNL1 is a deduced 370 amino acid protein which is predominantly expressed in skeletal muscle, prostate, lung, heart, small intestine, ovary and placenta tissues. MBNL1 and MBNL2, which associate with ex-panded CUG repeats in vitro, both localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders.
產(chǎn)品型號(hào)：bsm-62213R廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-03-03訪 問(wèn) 量： 147產(chǎn)品分類
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