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簡(jiǎn)要描述：Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.Involvement in disease:Defects in AXIN2 are involved in colorectal cancer (CRC). They appear to be specifically associated with defective mismatch repair.Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (ODCRCS). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable type
產(chǎn)品型號(hào)：bsm-61459R廠商性質(zhì)：生產(chǎn)廠家更新時(shí)間：2025-03-01訪 問(wèn) 量： 144產(chǎn)品分類
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